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Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides.
Sutter CH, Azim S, Wang A, Bhuju J, Simpson AS, Uberoi A, Grice EA, Sutter TR. Sutter CH, et al. J Invest Dermatol. 2023 Oct;143(10):1964-1972.e4. doi: 10.1016/j.jid.2023.03.1662. Epub 2023 Mar 31. J Invest Dermatol. 2023. PMID: 37004877
Tapinarof, an AHR ligand approved for the treatment of psoriasis, increased UGCG RNA, protein, and its lipid metabolites hexosylceramides as well as increased the RNA expression of ABCA12, GBA1, and SMPD1. In Ahr-null mice, Ugcg RNA and hexosylceramides were …
Tapinarof, an AHR ligand approved for the treatment of psoriasis, increased UGCG RNA, protein, and its lipid metabolites hexosylceram …
Dysregulated sphingolipid metabolism and autophagy in granulosa cells of women with endometriosis.
Turathum B, Gao EM, Grataitong K, Liu YB, Wang L, Dai X, Chian RC. Turathum B, et al. Front Endocrinol (Lausanne). 2022 Aug 3;13:906570. doi: 10.3389/fendo.2022.906570. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35992117 Free PMC article.
Gene expression involved in ceramide synthesis (CERS1, SPTL1, and SMPD1) and autophagy (BECN1, LAMP, and PC3) were significantly higher in CCs with endometriosis according to FASN, BECN1, and LAMP protein expressions. However, gene expression involved in ceramide synthesis …
Gene expression involved in ceramide synthesis (CERS1, SPTL1, and SMPD1) and autophagy (BECN1, LAMP, and PC3) were significantly high …
The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson's Disease.
Blokhin V, Shupik M, Gutner U, Pavlova E, Lebedev AT, Maloshitskaya O, Bogdanov V, Sokolov S, Alessenko A, Ugrumov M. Blokhin V, et al. Biomolecules. 2022 Jan 6;12(1):93. doi: 10.3390/biom12010093. Biomolecules. 2022. PMID: 35053241 Free PMC article.
Given the important role of sphingolipids in the pathogenesis of neurodegenerative diseases, we aimed to analyze the gene expression of key sphingolipid metabolism enzymes (ASAH1, ASAH2, CERS1, CERS3, CERS5, GBA1, SMPD1, SMPD2, UGCG) and the content of 32 sphingolip …
Given the important role of sphingolipids in the pathogenesis of neurodegenerative diseases, we aimed to analyze the gene expression of key …